defile. Greek. phtheiro. Same word as "destroy" below. Occurs also in 1Co_15:33. 2Co_7:2; 2Co_11:3. Eph_4:22. Jud_1:10. Rev_19:2 (corrupt). The word "mar" will suit both clauses. The man who mars God's Temple by introducing divisions, and the wisdom that is not from above (Jam_3:15), will himself be marred (1Co_3:15).
him = this one. Greek. houtos. Emphatic.
holy. Greek. hagios.
which = and such, i.e. holy, or separated. Omit "temple" in the last clause.