I commend you to God - the almighty Conservator of His people.
and to the word of his grace - that message of His pure grace (Act 20:24) by the faith of which He keeps us (1Pe 1:5).
which - that is, God.
is able to build you up, and to give you an inheritance, etc. - Observe how salvation - not only in its initial stages of pardon and regeneration, but in all its subsequent stages of “up-building,” even to its consummation in the final inheritance - is here ascribed to the “ability” of God to bestow it, as in Rom 16:25; Eph 3:20; particularly Jud 1:24; and compare 2Ti 1:12, where the same thing is ascribed to Christ.
among all them which are sanctified - Sanctification is here viewed as the final character and condition of the heirs of glory, regarded as one saved company.