the father of Publius lay sick of a fever - “fevers.” The word was often thus used in the plural number, probably to express recurring attacks.
and of a bloody flux - “of dysentery.” (The medical accuracy of our historian’s style has been observed here.)
to whom Paul entered in, and prayed - thereby precluding the supposition that any charm resided in himself.
and laid his hands on him, and healed him - Thus, as our Lord rewarded Peter for the use of his boat (Luk 5:3, Luk 5:4, etc.), so Paul richly repays Publius for his hospitality. Observe the fulfillment here of two things predicted in Mar 16:18 - the “taking up serpents,” and “recovering of the sick by laying hands on them.”