Take ... away from me - literally, “Take away, from upon Me”; the idea being that of a burden pressing upon the bearer. So Isa 1:14, “They are a trouble unto Me (literally, ‘a burden upon Me’): I am weary to bear them.”
the noise of thy songs - The hymns and instrumental music on sacred occasions are to Me nothing but a disagreeable noise.
I will not hear - Isaiah substitutes “prayers” (Isa 1:15) for the “songs” and “melody” here; but, like Amos, closes with “I will not hear.”