handfuls - expressing the paltry gain for which they bartered immortal souls (compare Mic 3:5, Mic 3:11; Heb 12:16). They “polluted” God by making His name the cloak under which they uttered falsehoods.
among my people - an aggravation of their sin, that they committed it “among the people” whom God had chosen as peculiarly His own, and among whom He had His temple. It would have been a sin to have done so even among the Gentiles, who knew not God; much more so among the people of God (compare Pro 28:21).
slay ... souls that should not die, etc. - to predict the slaying or perdition of the godly whom I will save. As true ministers are said to save and slay their hearers, according to the spirit respectively in which these receive their message (2Co 2:15, 2Co 2:16), so false ministers imitate them; but they promise safety to those on the broad way to ruin and predict ruin to those on the narrow way of God.
my people that hear your lies - who are therefore willfully deceived, so that their guilt lies at their own door (Joh 3:19).