Trust ye not in a friend - Faith is kept nowhere: all to a man are treacherous (Jer 9:2-6). When justice is perverted by the great, faith nowhere is safe. So, in gospel times of persecution, “a man’s foes are they of his own household” (Mat 10:35, Mat 10:36; Luk 12:53).
guide - a counselor [Calvin] able to help and advise (compare Psa 118:8, Psa 118:9; Psa 146:3). The head of your family, to whom all the members of the family would naturally repair in emergencies. Similarly the Hebrew is translated in Jos 22:14 and “chief friends” in Pro 16:28 [Grotius].
her that lieth in thy bosom - thy wife (Deu 13:6).