with mine own hand - not employing an amanuensis, as in other Epistles: a special compliment to Philemon which he ought to show his appreciation of by granting Paul’s request. Contrast Col 4:18, which shows that the Epistle to the Colossian Church, accompanying this Epistle, had only its closing “salutation†written by Paul’s own hand.
albeit, etc. - literally, “that I may not say ... not to say,†etc.
thou owest ... even thine own self - not merely thy possessions. For to my instrumentality thou owest thy salvation. So the debt which “he oweth thee†being transferred upon me (I making myself responsible for it) is cancelled.