Touch not - referring to Gen 26:11, where Abimelech says of Isaac, “He that toucheth this man or his wife shall surely be put to death.”
mine anointed - as specially consecrated to Me (Psa 2:2). The patriarch was the prophet, priest, and king of his family.
my prophets - in a similar sense, compare Gen 20:7. The “anointed” are those vessels of God, consecrated to His service, “in whom (as Pharaoh said of Joseph, Gen 41:38) the Spirit of God is” [Hengstenberg].