Cited literally from the Septuagint, Isa 29:14, except that the Septuagint has κρύψω I will conceal, instead of I will reject. The Hebrew reads: “The wisdom of its (Judah's) wise men shall perish, and the sagacity of its sagacious men shall hide itself.”
Wisdom - prudence (σοφίαν - σύνεσιν)
The two words are often found together, as Exo 31:3; Deu 4:6; Col 1:9. Compare σοφοὶ καὶ συνετοί wise and prudent, Mat 11:25. For the distinction, see, as to σοφία wisdom, on Rom 11:33; as to σύνεσις prudence, on Mar 12:33; Luk 2:47. Wisdom is the more general; mental excellence in its highest and fullest sense. Prudence is the special application of wisdom; its critical adjustment to particular cases.
Will bring to nothing (ἀθετήσω)
See on Luk 7:30. Originally, to make disestablished (ἄθετον) something which is established or prescribed (θετόν) Hence to nullify, make void, frustrate, and, in a milder sense, to despise or reject, as Gal 2:21. The stronger sense is better here, so that Rev., reject is not an improvement on the A.V. The American revisers render: And the discernment of the discerning will I bring to nought.