Wherein refers to the gospel. Κακοπαθεῖν only here, 2Ti 4:5, and Jam 5:13. lxx, Jon 4:10.
As an evildoer (ὡς κακοῦργος)
Only here and in Luke. Better, malefactor. The meaning is technical. Comp. Luk 23:32, Luk 23:33, Luk 23:39.
Unto bonds (μέχρι δεσμῶν)
Comp. Phi 2:8, μέχρι θανάτου unto death: Heb 12:4, μέχρις αἵματος unto blood. Const. with I suffer trouble.
But the word of God is not bound (ἀλλὰ ὁ λόγος τοῦ θεοῦ οὐ δέδεται)
Nevertheless, although I am in bonds, the gospel which I preach will prevail in spite of all human efforts to hinder it. Word of God often in Paul. In Pastorals, 1Ti 4:5; Tit 2:5. Bound, in Paul metaphorically, as here, Rom 7:2; 1Co 7:27, 1Co 7:39.