Paul's more usual form of expression is, I would not have you to be ignorant. See on Rom 1:13.
What great conflict I have (ἡλίκον ἀγῶνα ἔχω)
Rev., how greatly I strive. Ἡλίκον what great, only here and Jam 3:5. Conflict, continuing the metaphor of Col 1:29. Here of inward conflict, anxiety, prayer, as Col 4:12.
See on Rev 3:14.
And for as many as (καὶ ὅσοι)
Including all who come under the same category as the Colossians and Laodicaeans. Hence equivalent to all who, like yourselves, have not seen, etc. See, for a similar usage, Act 4:6; Rev 18:17. Indicating that the Colossians and Laodicaeans were both personally unknown to Paul.