Literally, when the wine failed. So Rev., Wyc., and wine failing. Some early authorities read: “they had no wine, for the wine of the marriage was consumed.” Marriage festivals sometimes lasted a whole week (Gen 29:27; Jdg 14:15; Tobit 9:1-2; 10:1).
They have no wine
Implying a request for help, not necessarily the expectation of a miracle.