Rev., holden. So Wyc. See on Mat 4:24. The word is used nine times by Luke, and only three times elsewhere. Paul uses it of the constraining of Christ's love (2Co 5:14), and of being in a strait (Phi 1:23). In Act 28:8, it is joined with fever, as here, and is a common medical term in the same sense.
A great fever (πυρετῷ μεγάλῳ)
Another mark of the physician. The epithet great is peculiar to Luke. The ancient physicians distinguished fevers into great and small.