Poured out without mixture (κεκερασμένου ἀκράτου)
Lit., which is mingled unmixed. From the universal custom of mixing wine with water for drinking, the word mingle came to be used in the general sense of prepare by putting into the cup. Hence, to pour out.
Cup of His anger
Compare Psa 75:8.
Brimstone (θείῳ)
Commonly taken as the neuter of θεῖος divine; that is, divine incense, since burning brimstone was regarded as having power to purify and to avert contagion. By others it is referred to θύω to burn, and hence to sacrifice.