In labour and travail (kopōi kai mochthōi). Both old words for severe work, combined here as in 1Th 2:9; 2Th 3:8, “by toil and moil” (Plummer). The rest of the list is like the items in 2Co 6:4.
In cold (en psuchei). Old word from psuchō, to cool by blowing. See Act 28:2. See the picture of the aged Paul later in the Roman dungeon (2Ti 4:9-18).