Praying always; i.e. in every opportunity, so often as our own or others’ necessities call us to it, 1Th_5:17.
With all prayer and supplication; prayer, when opposed to supplication, seems to signify petitioning for good things, and supplication the deprecating of evil, 1Ti_2:1.
In the Spirit; either our own spirit, with which we pray, so as not to draw nigh to God with our mouth only, as Isa_29:13; or rather, the Holy Spirit of God, by whose assistance we pray, Rom_8:26,27 Jude 1:20.
Watching thereunto; to prayer, in opposition to sloth and security: see Mat_26:41Col_4:21Pe_4:7.
With all perseverance; constancy and continuance in prayer in every condition, adverse as well as prosperous, though prayer be not presently answered, Luk_18:1.
And supplication for all saints; not only for ourselves, but for our brethren in the world, none being in so good a condition but they may need our prayers.