God’s armies, Isa_13:1-5. The destruction of Babylon by the Persians and Medes: their great distress and anguish; and their utter desolation, Isa_13:6-22.
The burden: this title is commonly given to sad prophecies, which indeed are grievous burdens to them upon whom they are laid. See 2Ki_9:25Jer_23:33,36.
Of Babylon; of the city and empire of Babylon by Cyrus, for their manifold and great sins, and in order to the deliverance of his people.