The kings; either those mentioned 2Sa 5 2Sa 8; or rather Herod the Great, and the other Herod, and Pilate, and others with or after them.
Of the earth; so called in way of contempt, and to show their madness in opposing the God of heaven.
Set themselves: the word notes their firm purpose and professed hostility, and the combination of their counsels and forces.
Against the Lord; either directly and professedly; or indirectly and by consequence, because against his anointed, and against his counsel and command. And; or, that is, as that particle is oft used; the latter clause explaining the former, and showing in what sense they fought against that God whom they pretended to own and worship.
Against his anointed; against such a king whom God hath chosen and exalted, and wonderfully accomplished and set up for his work and service, who therefore will certainly defend him against all his enemies.